HORSE-VC2QHTUZ6

AIRBabel's deterministic identifier, minted from the sequence (SPECIES-CODE+hash) i: a stable sequence-derived identifier, not an official allele name. This sequence's names from each source are listed under Allele names.

SpeciesEquus caballus LocusIGH TypeV FunctionalNone Length286 nt

IGHV3-73*01: a Equus caballus IGH V allele sequence, 286 nt, not recorded. The nucleotide and amino-acid sequence is below, with every recorded name and its source.

Species	Equus caballus (NCBITAXON:9796)
Locus / type	IGH / V
Functional i	None
Length	286 nt
Protein UID i	HORSE-VP-VCDWMK (shared by alleles with the same V-REGION amino-acid sequence)

Coding sequence (nt)

286 nt

GAGGTGCAGCTGGTGGAGTCTGGGGGAAGCTTGGTGCAGCCTGGGGGGTCTCTGAGCTCTCCAGTGCAGCTTCTGGGTTCAGCTTCAGTAGCTGCTGGATAATCTGGATCTGACAGGCTCCAGGGTAGGGCCTGTACTGGGCTGGTTGAACTCATACTGATGAAAGTAGAACTGACTCTGTGAAGGGCTGATTCACCATCTCTAGAGACAATGCCAAGAACATGCCTTTTCTGCAAGTGACAAGTGTGAGAACCAAGGGCACTGCCATGTGTTAGTGTTCAAGACA

Amino-acid sequence (V-REGION)

95 aa

EVQLVESGGSLVQPGGSLSSPVQLLGSASVAAG*SGSDRLQGRACTGLVELILMKVELTL*RADSPSLETMPRTCLFCK*QV*EPRALPCVSVQD

Translated here from the nucleotide sequence; no source published a protein for this allele. i

Name history i: formerly IGHV3-84*01 (to 2020-01-31);

Allele names i

Every name below denotes this exact sequence (HORSE-VC2QHTUZ6). None is canonical; they are labels, and the UID is the key.

Name	Scheme	Source(s)
IGHV3-73*01	IMGT	IMGT

Former IMGT names i

Former name	Last seen in IMGT release
*IGHV3-8401**	2020-01-31

External records i

IMGT: IGHV3-73*01

Literature references 22 total · 22 name-mentioned* i

PubMed publications linked to this allele. Name-mentioned entries were auto-collected by name match and may refer to a different same-named allele; treat them as leads, not ground truth.

PMID	Title	Evidence	Source
29545810	Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification.	name mentioned^*	literature_supp
29558968	BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data.	name mentioned^*	literature_supp
30697215	VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted/Founder gp120.	name mentioned^*	literature_supp
31839985	More than one antibody of individual B cells revealed by single-cell immune profiling.	name mentioned^*	literature_supp
32425948	AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.	name mentioned^*	literature_supp
33048842	Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing.	name mentioned^*	literature_supp
33485405	Enhancement versus neutralization by SARS-CoV-2 antibodies from a convalescent donor associates with distinct epitopes on the RBD.	name mentioned^*	literature_supp
33843586	Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth.	name mentioned^*	literature_supp
34242577	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.	name mentioned^*	literature_supp
34785098	Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients.	name mentioned^*	literature_supp
35837088	Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements.	name mentioned^*	literature_supp
36006380	Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens.	name mentioned^*	literature_supp
36328595	Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing.	name mentioned^*	literature_supp
36827454	Modeling and predicting the overlap of B- and T-cell receptor repertoires in healthy and SARS-CoV-2 infected individuals.	name mentioned^*	literature_supp
37368240	Memory B cell development elicited by mRNA booster vaccinations in the elderly.	name mentioned^*	literature_supp
38435425	Analysis of immunoglobulin/T-cell receptor repertoires by high-throughput RNA sequencing reveals a continuous dynamic of positive clonal selection in follicular lymphoma.	name mentioned^*	literature_supp
39840032	An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape.	name mentioned^*	literature_supp
40066131	Characterization of Immunoglobulin Heavy Locus Rearrangements in Molecular Subtypes of Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.	name mentioned^*	literature_supp
40664667	High-resolution mapping of single cells in spatial context.	name mentioned^*	literature_supp
41606257	Allergen-specific human IgE isolated through an allergen-agnostic pipeline-understanding immune response and allergen recognition.	name mentioned^*	literature_supp
41617721	Refined phenotyping of vaccine responses reveals transcriptomic determinants of neutralizing antibody heterogeneity.	name mentioned^*	literature_supp
42078068	B-cell immune repertoire analysis of autoimmune neurological syndromes with anti-GAD65 antibodies.	name mentioned^*	literature_supp

* matched by allele name only. The publication mentions this name, but AIRBabel cannot determine from the name alone whether it refers to this allele; the same name can denote a different allele in another species. This is useful for literature review but is not verified evidence.

Contributed by IMGT. See Sources & citations for each source's version, citation and licence.

RSS i

Recombination signal sequences flanking this allele. Click one to see every coding allele linked to that exact RSS variant.

Part	Sequence	Source	RSS UID
v_rs	CACAGTAACGGCGAGTCAGTGTGAGCCCAGACACAAGCC	IMGT	HORSE-R64AGM

Leader

Signal-peptide coding sequence (spliced exon 1 + exon 2). The genomic intron between the two exons is deferred.

Leader (exon 1 + exon 2)	Split	Source	Leader UID
ATGGAATATGGGCTGAGCTGGATTTTGCTTGTTGCTATTTTAGAAGGTGTCCAGGGT	46 + 11 nt	IMGT	HORSE-LPDDLC

Find similar (nt · aa · cross-species) i

Everything comparative about this sequence (the exact differences to other alleles, protein consequence, IMGT alignment, cross-species nearest) is shown per hit in the results of this query.

Ranks coding alleles by normalized edit-distance identity. Also available at /api/sequences/HORSE-VC2QHTUZ6/similar?min_identity=0.95&kind=nt.

API: JSON · AIRR AlleleDescription · aliases