AIRBabel immunoglobulin and T-cell receptor allele sequences · leaders · RSSs

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HUMAN-VKEVEYJ74

AIRBabel's deterministic identifier, minted from the sequence (SPECIES-CODE+hash) i: a stable sequence-derived identifier, not an official allele name. This sequence's names from each source are listed under Allele names.

SpeciesHomo sapiens LocusIGH TypeV FunctionalFalse Length298 nt

IGHV3-30-2*03, IGHV3-30-33*01, IGHV3-30-73*01: a Homo sapiens IGH V allele sequence, 298 nt, non-functional. The nucleotide and amino-acid sequence is below, with every recorded name and its source.

Earlier records of this allele i

IMGT has published this allele name over more than one sequence extent. Earlier sequence extents are deferred from default search results but remain resolvable, so a paper that cited one still leads here.

RecordNameLengthRelation to this recordIMGT releases
HUMAN-VPQC3NYGJ IGHV3-30-33*01 296 nt contained in this record 2016-12-19–2024-01-07
SpeciesHomo sapiens (NCBITAXON:9606)
Locus / typeIGH / V
Functional iFalse
Length298 nt
Protein UID iHUMAN-VP-TKZMLV (shared by alleles with the same V-REGION amino-acid sequence)

Coding sequence (nt)

298 nt
GAGGTACAGCTCGTGGAGTCCGGAGAGGACCCAAGACAACCTGGGGGATCCCTGAGACTCTCCTGTGCAGACTCTGGATTAACCTTCAGTAGCTACTGAAGGAGCTCGGTTTCCCAGGCTCCAGGGAAGGGGCTGGAGTGAGTAGTAGATATACAGTGTGATGGAAGTCAGATATGTTATGCATAATCTTTGAAGAGCAAATTCACCATCTCCAAAGAAAATGCCAAGAACTCACTGTATTTGCTAATGAACAGTCTGAGAGCAGAGGGCACAGCTGTGTGTTACTGTATGTGAGGCA

Amino-acid sequence (V-REGION)

99 aa
EVQLVESGEDPRQPGGSLRLSCADSGLTFSSY*RSSVSQAPGKGLE*VVDIQCDGSQICYA*SLKSKFTISKENAKNSLYLLMNSLRAEGTAVCYCM*G

Published by the source, and consistent with the nucleotide sequence above. i

Name history i: re-cut from IGHV3-30-33*01 (296 nt);

Allele names i

Every name below denotes this exact sequence (HUMAN-VKEVEYJ74). None is canonical; they are labels, and the UID is the key.

Multiple allele designations. This one sequence is recorded under 3 different allele designations: IGHV3-30-2*03, IGHV3-30-33*01, IGHV3-30-73*01. These are identical normalized nucleotide sequences with different attributed names.

NameSchemeSource(s)
IGHV3-30-2*03 IMGT IMGT
IGHV3-30-33*01 IMGT IMGT
IGHV3-30-73*01 IMGT IMGT

Other names & identifiers

Alternative and former names, e.g. IMGT clone names, plus accession identifiers.

NameKindSource(s)
AC244456.2 NCBI accession ncbi_nucleotide

External records i

NCBI nucleotide: link GenBank: GENBANK:AC244456 GenBank: GENBANK:IMGT000173 GenBank: GENBANK:IMGT000315 IMGT: IGHV3-30-2*03

Literature references 4 total · 4 name-mentioned* i

PubMed publications linked to this allele. Name-mentioned entries were auto-collected by name match and may refer to a different same-named allele; treat them as leads, not ground truth.

PMIDTitleEvidenceSource
34484220 RAPID: A Rep-Seq Dataset Analysis Platform With an Integrated Antibody Database. name mentioned* literature_supp
34764956 Novel Allele Detection Tool Benchmark and Application With Antibody Repertoire Sequencing Dataset. name mentioned* literature_supp
36328595 Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing. name mentioned* literature_supp
42078068 B-cell immune repertoire analysis of autoimmune neurological syndromes with anti-GAD65 antibodies. name mentioned* literature_supp

* matched by allele name only. The publication mentions this name, but AIRBabel cannot determine from the name alone whether it refers to this allele; the same name can denote a different allele in another species. This is useful for literature review but is not verified evidence.

Contributed by IMGT, ncbi_nucleotide. See Sources & citations for each source's version, citation and licence.

RSS i

Recombination signal sequences flanking this allele. Click one to see every coding allele linked to that exact RSS variant.

PartSequenceSourceRSS UID
v_rsCCAGGTAAGAAGACATCAGTGTGAACACAGACACAGAGT IMGT HUMAN-RI2D2Y

Leader

Signal-peptide coding sequence (spliced exon 1 + exon 2). The genomic intron between the two exons is deferred.

Leader (exon 1 + exon 2)SplitSourceLeader UID
ATGGAGCTTGGGCTGAGCTGGGTTTTCACTGTTGCTGTTTTAAAAGGTGTCTAGTGA 46 + 11 nt IMGT HUMAN-LUA42A

Find similar (nt · aa · cross-species) i

Everything comparative about this sequence (the exact differences to other alleles, protein consequence, IMGT alignment, cross-species nearest) is shown per hit in the results of this query.

Ranks coding alleles by normalized edit-distance identity. Also available at /api/sequences/HUMAN-VKEVEYJ74/similar?min_identity=0.95&kind=nt.