AIRBabel immunoglobulin and T-cell receptor allele sequences · leaders · RSSs

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RHESUS-VFCUMQOPS

AIRBabel's deterministic identifier, minted from the sequence (SPECIES-CODE+hash) i: a stable sequence-derived identifier, not an official allele name. This sequence's names from each source are listed under Allele names.

SpeciesMacaca mulatta LocusIGH TypeV FunctionalTrue Length301 nt
SpeciesMacaca mulatta (NCBITAXON:9544)
Locus / typeIGH / V
Functional iTrue
Length301 nt
Protein UID iRHESUS-VP-JQ6XSI (shared by alleles with the same V-REGION amino-acid sequence)

Allele names i

Every name below denotes this exact sequence (RHESUS-VFCUMQOPS). None is canonical; they are labels, and the UID is the key.

Multiple allele designations. This one sequence is recorded under 4 different allele designations: IGHV2-7*02_W4118, IGHV2-10*02, IGHV2-7*02_S1732, IGHV2-ACK*01. These are identical normalized nucleotide sequences with different attributed names.

NameSchemeSource(s)
IGHV2-7*02_W4118 Guo Guo
IGHV2-2YU6*03 IgLabel MUSA
IGHV2-V7ET*06 IgLabel OGRDB
IGHV2-10*02 IMGT IMGT
IGHV2-7*02_S1732 KIMDB KIMDB
IGHV2-ACK*01 RhGLDB+ RhGLDB+

External records i

genbank:MF989451: GENBANK:MF989451 GenBank: GENBANK:IMGT000099 IMGT: IGHV2-10*02 OGRDB: IGHV2-V7ET*06

Literature references 8 total · 1 verified · 5 sequence-in-paper · 2 name-mentioned* i

PubMed publications linked to this allele. A sequence-in-paper match indicates that this allele's exact sequence was detected in the publication text or supplementary material; it is sequence-level evidence. Name-mentioned entries were auto-collected by name match and may refer to a different same-named allele; treat them as leads, not ground truth.

PMIDTitleEvidenceSource
29163486 verified MUSA
32866207 Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. sequence in paper literature_supp
35419009 Addressing IGHV Gene Structural Diversity Enhances Immunoglobulin Repertoire Analysis: Lessons From Rhesus Macaque. sequence in paper literature_supp
38707998 Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque. sequence in paper literature_supp
39068149 Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques. sequence in paper literature_supp
41392054 Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates. sequence in paper literature_supp
36405682 Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies. name mentioned* literature_supp
38042809 Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates. name mentioned* literature_supp

* matched by allele name only. The publication mentions this name, but AIRBabel cannot determine from the name alone whether it refers to this allele; the same name can denote a different allele in another species. This is useful for literature review but is not verified evidence.

Contributed by Guo, IMGT, KIMDB, MUSA, OGRDB, RhGLDB+. See Sources & citations for each source's version, citation and licence.

RSS i

Recombination signal sequences flanking this allele. Click one to see every coding allele linked to that exact RSS variant.

PartSequenceSourceRSS UID
v_rsCACAGAGACACAGCTCAGGGCGCCTCCTGTACAAGAACC IMGT MUSA RHESUS-RSOBSS

Leader

Signal-peptide coding sequence (spliced exon 1 + exon 2). The genomic intron between the two exons is deferred.

Leader (exon 1 + exon 2)SplitSourceLeader UID
ATGGACACGCTTTGCTCCACGCTCCTGCTGCTGACCGTCCCTTCATGTGGGTCTTCTCC 48 + 11 nt MUSA RHESUS-LH2AIF
ATGGACACGCTTTGCTCCACGCTCCTGCTGCTGACCGTCCCTTCATGGGTCTTCTCC 46 + 11 nt IMGT RHESUS-LQGPMH

Find similar alleles

Ranks coding alleles by normalized edit-distance identity. Also available at /api/sequences/RHESUS-VFCUMQOPS/similar?min_identity=0.95&kind=nt.

Coding sequence (nt)

301 nt
CAGGTGACCTTGAAGGAGTCTGGTCCTGCGCTAGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTTCTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAGAACCAGGTTGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGAGAC

Amino-acid sequence (V-REGION)

100 aa
QVTLKESGPALVKPTQTLTLTCTFSGFSLSTSGMRVSWIRQPPGKALEWLARIDWDDDKYYSTSLKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCARR

Published by the source, and consistent with the nucleotide sequence above. i