AIRBabel immunoglobulin and T-cell receptor allele sequences · leaders · RSSs

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RHESUS-VGNMXOXAT

AIRBabel's deterministic identifier, minted from the sequence (SPECIES-CODE+hash) i: a stable sequence-derived identifier, not an official allele name. This sequence's names from each source are listed under Allele names.

SpeciesMacaca mulatta LocusIGH TypeV FunctionalTrue Length302 nt
SpeciesMacaca mulatta (NCBITAXON:9544)
Locus / typeIGH / V
Functional iTrue
Length302 nt
Protein UID iRHESUS-VP-ILAAVZ (shared by alleles with the same V-REGION amino-acid sequence)

Allele names i

Every name below denotes this exact sequence (RHESUS-VGNMXOXAT). None is canonical; they are labels, and the UID is the key.

Multiple allele designations. This one sequence is recorded under 2 different allele designations: IGHV3-NL_18*01_W9761, IGHV3-186*02. These are identical normalized nucleotide sequences with different attributed names.

NameSchemeSource(s)
IGHV3-NL_18*01_W9761 Guo Guo
IGHV9-7U4O*01 IgLabel MUSA
IGHV9-DH64*08 IgLabel OGRDB
IGHV3-186*02 IMGT IMGT

Other names & identifiers

Alternative and former names, e.g. IMGT clone names, plus accession identifiers.

NameKindSource(s)
NW_001121240.1 NCBI accession ncbi_nucleotide

Former IMGT names i

Former nameLast seen in IMGT release
IGHV3-5*012019-03-01

External records i

NCBI nucleotide: link NCBI Gene: NCBIGENE:714939 GenBank: GENBANK:NW_001121240 IMGT: IGHV3-186*02 OGRDB: IGHV9-DH64*08

Literature references 8 total · 1 sequence-in-paper · 7 name-mentioned* i

PubMed publications linked to this allele. A sequence-in-paper match indicates that this allele's exact sequence was detected in the publication text or supplementary material; it is sequence-level evidence. Name-mentioned entries were auto-collected by name match and may refer to a different same-named allele; treat them as leads, not ground truth.

PMIDTitleEvidenceSource
35419009 Addressing IGHV Gene Structural Diversity Enhances Immunoglobulin Repertoire Analysis: Lessons From Rhesus Macaque. sequence in paper literature_supp
29545792 Coupling of Single Molecule, Long Read Sequencing with IMGT/HighV-QUEST Analysis Expedites Identification of SIV gp140-Specific Antibodies from scFv Phage Display Libraries. name mentioned* literature_supp
38961347 Systematic characterization of immunoglobulin loci and deep sequencing of the expressed repertoire in the Atlantic cod (Gadus morhua). name mentioned* literature_supp
39068149 Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques. name mentioned* literature_supp
39698082 Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten. name mentioned* literature_supp
41392054 Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates. name mentioned* literature_supp
41410768 Convergent mutation trajectories convert functional self-tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody. name mentioned* literature_supp
41876881 Development of canine parvovirus-neutralizing monoclonal antibodies from natural host and their germline gene usage. name mentioned* literature_supp

* matched by allele name only. The publication mentions this name, but AIRBabel cannot determine from the name alone whether it refers to this allele; the same name can denote a different allele in another species. This is useful for literature review but is not verified evidence.

Contributed by Guo, IMGT, MUSA, OGRDB, ncbi_nucleotide. See Sources & citations for each source's version, citation and licence.

RSS i

Recombination signal sequences flanking this allele. Click one to see every coding allele linked to that exact RSS variant.

PartSequenceSourceRSS UID
v_rsCACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC IMGT MUSA RHESUS-R6AAZB

Leader

Signal-peptide coding sequence (spliced exon 1 + exon 2). The genomic intron between the two exons is deferred.

Leader (exon 1 + exon 2)SplitSourceLeader UID
ATGGAGTTTGTACTGAGCTGGGTTTTCCTTGTTGCCATTTTAAAAGGTGCCCAGTGT 46 + 11 nt IMGT RHESUS-LCEERN
ATGGAGTTTGTACTGAGCTGGGTTTTCCTTGTTGCCATTTTAAAAGGTGTGCCCAGTGT 48 + 11 nt MUSA RHESUS-LKRR6I

Find similar alleles

Ranks coding alleles by normalized edit-distance identity. Also available at /api/sequences/RHESUS-VGNMXOXAT/similar?min_identity=0.95&kind=nt.

Coding sequence (nt)

302 nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGCGGGTCCCTGAGACCCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGTTCTGCTATGCACTGGGTCCGCCAGGCTTCTGGGAAAGGACTGGAGTGGGTTGGACGTATTAGAAGCAAATCTAACAATTACGCGACAGAATACGCCGCATCGGTGAAAGGCAGATTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGA

Amino-acid sequence (V-REGION)

100 aa
EVQLVESGGGLVQPGGSLRPSCAASGFTFSSSAMHWVRQASGKGLEWVGRIRSKSNNYATEYAASVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCAR

Published by the source, and consistent with the nucleotide sequence above. i